# How long would your nail grow in an week!? 🤔 - Discussion on Khushi and Prithviraj sir's work

**URL:** https://metastudio.org/t/how-long-would-your-nail-grow-in-an-week-discussion-on-khushi-and-prithviraj-sirs-work/14485
**Category:** CUBE chat
**Tags:** project, english, image, science-process
**Created:** [May 8, 2023, 1:39am UTC](https://metastudio.org/t/how-long-would-your-nail-grow-in-an-week-discussion-on-khushi-and-prithviraj-sirs-work/14485 "2023-05-08T01:39:48Z")
**Posts on this page:** 1
**Page:** 1

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### Author: ![Smiti](https://metastudio.org/letter_avatar_proxy/v4/letter/s/3d9bf3/32.png) [@Smiti](https://metastudio.org/u/Smiti)
#### Post date: [May 8, 2023, 1:39am UTC](https://metastudio.org/t/how-long-would-your-nail-grow-in-an-week-discussion-on-khushi-and-prithviraj-sirs-work/14485/1 "2023-05-08T01:39:48Z")

</div>

![IMG-20230502-WA0023(1)](https://metastudio.org/uploads/default/original/2X/8/8342c4895623b1b19d1f183687fb69f22c2f68ba.jpeg)  
✨ On 2nd May 2023 we started discussion with **khushi’s experiment on nail regeneration**  
✨ Khushi presented nail regeneration and it’s connection with acne and hair fall in [an orientation program for RIE (NCERT) Bhopal students](https://metastudio.org/t/orientation-to-cube-cube-home-lab-movement-cube-chatshaala-with-students-of-regional-institute-of-education-ncert-bhopal/14410) on 24th April she got inspired to perform this work  
✨ Where Khushi told that she **will be cutting the nails** she has been **collecting data** from, **once a week**  
✨ There was a question on **how long the nail would grow in a week**  
✨ Majority believed in it would **grow between 1-2 mm** but @Theertha told it could be more than 2mm and according to @dhanraj7 it should be upto 1mm, not more than that  
✨ So let’s design an experiment **to see how long our nail grows in a week** - if this bold part is our **aim,** please try to **design an experiment** around it by writing  
**2) Requirements**  
**3) Procedure**  
**4) Expectations**  
**5) Observation** - way of collecting data (i would prefer uploading data on metastudio so it would be easy to maintain it and find it anytime needed)  
**6) Result & Conclusion**

 ![IMG-20230502-WA0024(1)](https://metastudio.org/uploads/default/original/2X/7/7913d791a36e0ac0e09e5f2bbaeaabd96e2538a0.jpeg)  
Take this image and reference given below as a hint to design your experiment!

Nail anatomy  
[https://www.ncbi.nlm.nih.gov/books/NBK534769/figure/article-25507.image.f2/?report=objectonly](https://www.ncbi.nlm.nih.gov/books/NBK534769/figure/article-25507.image.f2/?report=objectonly)

> [@Nail Growth: How Do We Measure?](https://metastudio.org/t/nail-growth-how-do-we-measure/165):
>
> [This activity is part of the Nail Growth activity. If you haven’t done that, please do that by clicking this link.](https://stemgames.metastudio.org/t/invitation-game-what-can-voter-s-ink-mark-do/78/11) In this activity we will measure the growth of nail from the picture taken on paper with a ruler or on graph paper. We can use an app; for example ImageMeter. Use link to download the application from playstore: [Please click this link to know steps to measure length using ImageMeter app](https://stemgames.metastudio.org/t/detail-version-of-how-to-use-image-meter-for-nail-measurement/363?u=jaikishan) You can use other apps as well Using this application we can mark the position from the be…

✨ Then we discussed about **what error we might get and how can we get precise and accurate data**  
Precision and accuracy are two ways that scientists think about error. Accuracy refers to how close a measurement is to the true or accepted value. Precision refers to how close measurements of the same item are to each other. Precision is independent of accuracy. That means it is possible to be very precise but not very accurate, and it is also possible to be accurate without being precise. The best quality scientific observations are both accurate and precise.  
[https://manoa.hawaii.edu/exploringourfluidearth/physical/world-ocean/map-distortion/practices-science-precision-vs-accuracy#:~:text=Accuracy%20refers%20to%20how%20close,Precision%20is%20independent%20of%20accuracy](https://manoa.hawaii.edu/exploringourfluidearth/physical/world-ocean/map-distortion/practices-science-precision-vs-accuracy#:~:text=Accuracy%20refers%20to%20how%20close,Precision%20is%20independent%20of%20accuracy).

✨ Here @anindita8820 explained that we can **take observation for like 4 week** and if we **observe growth between 2 numbers** let’s say **between 1-2mm** we can precisely say that this is the **standard range** and to actually standardize it we can **perform same experiment with various people** and see if we get **results in same range**

 ![IMG-20230504-WA0018(2)](https://metastudio.org/uploads/default/original/2X/1/11aae38d46594b2fc6bf5a9a78d64fc8024f710f.jpeg)

✨ On 4th May we continued discussion about **Prithviraj sir’s work on nail on nail growth**  
✨ This **picture was taken after applying nail paint** on **1st may** by Prithviraj sir  
✨ Here we can see nail paint has been **applied on index finger** (one which is towards the bottom side) and **middle finger**

 ![IMG-20230504-WA0016(1)](https://metastudio.org/uploads/default/original/2X/6/6608b8ad071450d67d770589c6e9760ba51440a9.jpeg)

✨ These are same nails _ **after 4 days** _ of applying nail paint  
✨ Here we can see he has applied nail paint on index finger and middle finger and **index finger is made rough with knife** before applying **nail paint** so that it **will stay on nail for longer period of time** as some nail paints peels off easily after drying  
✨ This picture has been taken after 4 days of applying nail paint, do you observe any nail growth yet ⁉ Cause i can’t see any growth here

 ![IMG-20230504-WA0015(1)](https://metastudio.org/uploads/default/original/2X/a/aa3cb223907d50fb930572c26c5fd909505fcb6e.jpeg)  
✨ According to **khushi’s observation, in 3 days** there is **1mm growth** in an **20 year old adult female** and **3 year old boy** but **in 60 year old female it’s 0.9mm growth**  
✨ **Why is there such differences seen in 20 year old female and 60 year old female?** Anyway it’s just **0.1 mm difference** which **isn’t a big deal** but more shocking 😲 fact is **we can see nail growth in 60 year old female that too within 3 days** but there is **on growth in 75 year old male’s nail even after 4 days!?** (According to Prithviraj sir’s data)… Why do we see such differences here ❓  
✨ Here we also discussed about **how to measure nail growth?** We can measure it **by measuring the gap between the nail paint mark and proximal end** of nail (nail cuticles) as nail grows for proximal end

 ![IMG-20230506-WA0021(1)](https://metastudio.org/uploads/default/original/2X/1/1bb4875cba17f86068c886f5ce59e17bf957e38e.jpeg)  
✨ As we were discussing about nail growth and khushi’s work on same @KiranKalakotiR ma’am asked me to hypothesize **how long a nail would grow in a week for different age of _male and female_**  
✨ I have heard that **in females nail growth is 📈 _faster_ than males** and **rate of growth _decreases_ 📉 as we grow old.** So i made hypothesis accordingly (upper right of whiteboard)  
✨ There was a question asked by @magpie ma’am that **does hormone affect nail growth and are these hormones common in male and female?** In female it’s estrogen _(according to first reference shared below 👇)_ **But in m  
males? Can we find it out ❓**  
✨ Also we were looking for **what affects rate of nail growth** to see that we were **looking for mutants that do not have nails** in both fingers and toes  
✨ There we got to know about **Anonychia Congenita which is a rare autosomal-recessive disorder** characterized by the absence of finger- and toe nails _(according to 2nd reference shared below 👇)_  
✨ According to @khushi this **disorder is related or associated with a wide variety of syndromes** _(according to 3rd reference shared below 👇)_ and here i got super confuse because of that reference and the word syndrome  
✨ So to know the **meaning of word syndrome** @Himanshu sir asked us to first discuss about **what are signs and symptoms…**  
✨ In very easy way we can say that **a symptom** is something that is **happening with patient** and they notice those **changes** like if we talk about **diabetes** then **if someone feels hungry most of the time, has a blurry vision and urinates frequently, etc** then these are **symptoms** that a patient would observe _**(Patient’s perspective)**_ but when that person would **go to doctor** then Dr would **perform tests** and there if **blood glucose level has increased** then it’s a **sign** that is **_Doctor’s perspective_**  
✨ Now we know what is a sign and what is a symptom… **So what is a syndrome?**  
✨ Syndrome is **a group of signs and symptoms occuring together and that is and covary over time** _(according to 4th reference shared below 👇)…_ **This** is something **I Never Knew Earlier,** yes that was my _ **TINKE moment!** _

1. Estrogen therapy has a beneficial effect upon collagen, thus improving the texture of the skin, the nails, the intervertebral discs and bone matrix. Discussion of side-effects should not be avoided, particularly the 1% extra lifetime risk of breast cancer.  
[https://pubmed.ncbi.nlm.nih.gov/20424287/#:~:text=Estrogen%20therapy%20has%20a%20beneficial,lifetime%20risk%20of%20breast%20cancer](https://pubmed.ncbi.nlm.nih.gov/20424287/#:~:text=Estrogen%20therapy%20has%20a%20beneficial,lifetime%20risk%20of%20breast%20cancer).

2. RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4. Congenital anonychia is a rare autosomal-recessive disorder characterized by the absence of finger- and toenails. Recently, we and others identified the secreted Wnt signaling ligand R-spondin 4 (RSPO4) as the first gene known to be responsible for inherited anonychia. R-spondins are secreted proteins that activate the Wnt/β-catenin signaling pathway. This puts anonychia on the growing list of congenital malformation syndromes caused by Wnt signaling pathway defects.  
[https://scholar.google.com/scholar?hl=en&as\_sdt=0%2C5&q=mutation+that+causes+Anonychia+congenita&btnG=#d=gs\_qabs&t=1683386414088&u=%23p%3D8CgliFBYa1AJ](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=mutation+that+causes+Anonychia+congenita&btnG=#d=gs_qabs&t=1683386414088&u=%23p%3D8CgliFBYa1AJ)

3. Congenital anonychia has been described in association with a wide variety of other congenital anomalies like nail-patella syndrome, DOOR syndrome (deafness, onychodystrophy, osteodystrophy and mental retardation), AEC syndrome (ankyloblepharon, ectodermal defects, cleft lip/palate), EEC syndrome (ectodactyly, ectodermal dysplasia, cleft lip/palate), TOOD syndrome (tricho-odonto-onycho-dermal), hypohidrotic ectodermal dysplasia with multiple anomalies and various craniofacial malformation syndromes 2. As an underlying bone is a prerequisite for the development of a normal nail, anonychia or hyponychia may occur when the terminal phalynx is either hypoplastic or completely absent 10. Simple anonychia, meaning the congenital absence of the nails without any other coexisting major congenital anomaly, is an extremely rare variety of this condition. This is mostly due to autosomal recessive inheritance. Isolated anonychia without any associated phenotypical disturbances is one of the rarest anomalies of congenital nail disorders. Some or all fingers of the hands or feet could be affected. Anonychia can also be encountered in dermatologic disorders like pemphigus, lichen planus, icthyosis, severe infection, severe allergic contact dermatitis, self-inflicted trauma, Raynaud phenomenon, severe exfoliative diseases, epidermolysis bullosa, and as a sequel of Stevens-Johnson syndrome  
[https://healthjade.net/anonychia/](https://healthjade.net/anonychia/)

4. A syndrome is a constellation of signs and symptoms that occur together and covary over time. A disorder is also a collection of signs and symptoms, but it has known associated features that are presumed to be related.  
[https://www.google.com/url?sa=t&source=web&rct=j&url=https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118625392.wbecp154%23:~:text%3DA%2520syndrome%2520is%2520a%2520constellation,are%2520presumed%2520to%2520be%2520related.&ved=2ahUKEwjo-uPpieH-AhUIsFYBHXYVB3kQFnoECBQQBQ&usg=AOvVaw166dXngTFExojNl4QdRCB\_](https://www.google.com/url?sa=t&source=web&rct=j&url=https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118625392.wbecp154%23:~:text%3DA%2520syndrome%2520is%2520a%2520constellation,are%2520presumed%2520to%2520be%2520related.&ved=2ahUKEwjo-uPpieH-AhUIsFYBHXYVB3kQFnoECBQQBQ&usg=AOvVaw166dXngTFExojNl4QdRCB_)

5. [https://images.app.goo.gl/r6kZBYJ22WjEbTeh9](https://images.app.goo.gl/r6kZBYJ22WjEbTeh9)

6. Anonychia congenita is a condition that affects the fingernails and toenails. Individuals with this condition are typically missing all of their fingernails and toenails (anonychia). This absence of nails is noticeable from birth (congenital). [https://medlineplus.gov/genetics/condition/anonychia-congenita/#:~:text=Anonychia%20congenita%20is%20a%20condition,noticeable%20from%20birth%20(congenital)](https://medlineplus.gov/genetics/condition/anonychia-congenita/#:~:text=Anonychia%20congenita%20is%20a%20condition,noticeable%20from%20birth%20(congenital)).

7. [https://www.sciencedirect.com/topics/medicine-and-dentistry/anonychia](https://www.sciencedirect.com/topics/medicine-and-dentistry/anonychia)

8. Anonychia refers to the absence of nail plates owing to an autosomal dominant or recessive inheritance. Congenital anonychia is a rare condition that may be associated with other ectodermal or mesodermal malformations like epidermolysis bullosa, (deafness, onychodystrophy, osteodystrophy, and mental retardation) syndrome and Iso-Kikuchi syndrome. Here, we report 3 cases with anonychia congenita appearing in different generations of a single family in Kingdom of Saudi Arabia [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841626/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841626/)

9. [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/syndrome](https://www.cancer.gov/publications/dictionaries/cancer-terms/def/syndrome)