S1E67 CUBE Chatshaala: Exploring New ways of Learning

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Timing:5.30 pm to 9.00 pm
Webinar will be recorded and recording link will be post in the same thread after the webinar.

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CUBE Chatshaala on 21st August 2020.

IMG-20200821-WA0058
This CUBE Chatshaala whiteboard illustrates the discussion on comparison between the sleep-wake cycle of 2 great model systems. The genes responsible for this cycle in fruit flies is studied along with the genes responsible for this cycle in phyllanthus plant. The activity pattern of phyllanthus is shown on the graph. Data collection of this model system is done by Lakshmy (a CUBist from SN College Nattika, Kerala) and is explained by @saswathy679 ( Aswathy) her collaborator. Expected data and observed data of the sleep-wake cycle of phyllanthus plant (including factors like sunrise and sunset time at different locations) is plotted on the graph. The pink line in the graph indicates the effect of 24 hrs continuous light on the sleep-wake pattern of the phyllanthus plant. Quite interesting discussion!

33 CUBists from 33 centres joined the webinar.

Breach Candy, South Mumbai: Arunan MC
Mumbai, Maharashtra: Abhijeet Singh
Thane, Maharashtra: Anshu Kadam
Kozhikode, Kerala: Arunima Kunju
Thriprayar, Kerala: Aswathy Suresh
Dadri, Uttar Pradesh: Bivas Nag
Nerul, Navi Mumbai: Drishtant M Kawale
Worli, Maharashtra: Isha Pawle
Moradabad, Uttar Pradesh: Kiran Yadav
Bhind, MP: Komal Suman Singh
Dumka, Jharkhand: Kshipra
Kandassankadavu, Kerala: Lakshmy PJ
Powai, Mumbai: Lydia Mathew
Andheri, Mumbai: Mandar Chavan
Ranchi, Jharkhand: Manjuel Jojo
Bangalore, Karnataka: Manohar GM
Byculla, Mumbai: Nazish Kaunchale
Mulund, Mumbai: Omkar Badnale
DSC, Delhi: P. Chitralekha
Mysore, Karnataka: Raghu Ram Achar
Chandigarh: Rajat Sudhir
Morabadi, Ranchi: Rechel Tirkey
Bandra, Mumbai: Saida Sayyed
Aurangabad, Maharashtra: Shivam Kumar Sriwas
Panvel, Maharashtra: Shraddha Sonavane
Thanniam, Kerala: Sidhy PP
Goa: Sucheta Naik
Sonari, Assam: Susanta Tanti
Thrissur, Kerala: Thampuru Bhaskaran
Cochin, Kerala: Vineeth Kumar
Alekhya
Leena
Sreedevi Menon

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[11:12 am, 22/08/2020] Lakshmy CUBE Kerala:

Summary of CUBE chatasaala 21/8/2020 discussion by Lakshmy from Thrissur, Kerala

Yesterday we have great discussion about circadian rhythm comparative study on drosophila and phyllanthus.

Aswathy draw an approximate graf about sleep wake cycle of phyllanthus and drosophila of 3 days with respect to sunrise (6am) and sunset time (6pm)

Aswathy expected that the number of fruit flies started to increase at sunrise time and and started decreasing at sunset time. But according to her original data, even after sunset there is maximum number of fruit flies (8pm) . Then after the number of fruit flies decreased.

Saida explained about the molecular aspects of circadian rhythm in fruit flies, ie, the mechanism of PER &TIM genes in drosophila. She said that the production of PER &TIM protein is maximum during sunset time .And later these proteins bind together and move from cytoplasm to nucleus and take away the CIK& CYC transcription factors and prevent the expression of PER &TIM genes. That induce sleep in drosophila. Saida initially expected that the number of fruit flies decreased from the sunset time onwards. But aswathy result is slightly different.

But Arunan Sir explained it with a simple
Example that even after switch of the AC there will be still cooling in the room for some time. Like that even though the production of PER proteins is maximum at sunset time even after that the proteins will be produced.

Later Lakshmy also explained about the circadian rhythm molecular mechanism in Arabidopsis thaliana. There is three genes responsible for circadian rhythm.

1.CCA1(CIRCADIAN CLOCK ASSOCIATED 1)
2. LHY (LATE ELONGATED HYPOCOTYL)
3. TOC1 (TIMING OF CAB EXPRESSION 1)

CCA1 &LHY function is same as PER& TIM gene in drosophila.

CCA1 &LHY gene production is maximum during sunrise time. Later these proteins bind together and later bind to the TOC1 promoter region and prevent the expression during day time. During evening time the expression of TOC1 is maximum that induced sleep .

Understanding sleep wake cycle of both phyllanthus and drosophila was really informative.

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