S1E70 CUBE Chatshaala: Exploring New ways of Learning

Meeting URL:

webinar.hbcse.tifr.res.in

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Timing:5.30 pm to 9.00 pm
Webinar will be recorded and recording link will be post in the same thread after the webinar.

Looking forward to your participation.
Thanks.

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CUBist from Kerala describing the current status of the fruit fly single line culture from the home lab. The description was needed in order to familiarise our newly joined CUBists from Goa. We can see on the whiteboard that the fruit fly model organism is a vast model by which we can touch upon several areas in Science. We have a Six-time Nobel Prize-winning model in our kitty!

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CUBist from Mumbai sharing a BREAKING NEWS related to the Single Line Culture of fruit flies which was started in the home lab. The procedure followed during the preparing of the culture medium, the names of the Single Line Culture bottles and the expectations of the coming days were discussed. The major observation was seeing the larvae on the 4th-day post-transfer of a single gravid female fruitfly!

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The objective with which CUBists are moving ahead is being discussed here. Coming back to the Nobel Prize, over a century of work on the fruit fly model from the time of Thomas Morgan till the recent Nobel Prize in 2017 and so on, advancements have been made in the field of Biology by using this model. These advancements have helped the scientists gather information which is useful for the sake of humanity like the Nobel Prizes in Immunology, Developmental Biology, Sleep-wake cycle, Genetics.

Later, the discussion was shifted to the plant model Cardamine where the experiment on the germination was looked upon and the observations were discussed.

Credits for the Images (all): @KiranyadavR

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CUBE Chatshaala on 24th August 2020.
49 CUBists from 46 centres joined the webinar.

Breach Candy, South Mumbai: Arunan MC
Ghatkopar, Mumbai: Aashutosh Mule
Varkala, Kerala: Aavani RG
Muvattapuzha, Kerala: Abhijith Vinod
Ghatkopar, Mumbai: Anjani Kashyap
Thane, Maharashtra: Anshu Kadam
Kalyan, Maharashtra: Apoorva Satpute
Kozhikode, Kerala: Arunima Kunju
Thriprayar, Kerala: Aswathy Suresh
Ahmedabad, Gujarat: Ayushi
Goa: Chiquita
Goregaon, Mumbai: Deepak Sharma
Nerul, Navi Mumbai: Drishtant M Kawale
Goa: Heena Goswami
Kanpur, Uttar Pradesh: Hina Mudgal
Worli, Maharashtra: Isha Pawle
Jamia Millia Islamia, New Delhi: Kanishka Parashar
Moradabad, Uttar Pradesh: Kiran Yadav
Bhind, MP: Komal Suman Singh
Patna, Bihar: Kriti
Dumka, Jharkhand: Kshipra
Goa: Latisha Gaonkar
Powai, Mumbai: Lydia Mathew
Ranchi, Jharkhand: Manjuel Jojo
Byculla, Mumbai: Nazish Kaunchale
Goa: Nidhi Kapileshwari
Mulund, Mumbai: Omkar Badnale
DSC, Delhi: P. Chitralekha
Faridabad, Haryana: Rahul Kushwaha
Morabadi, Ranchi: Rechel Tirkey
Bandra, Maharashtra: Saida Sayyed
Morabadi, Ranchi: Shalini Lal
Mumbai, Maharashtra: Shama Sayyed
Thanniam, Kerala: Sidhy PP
Mangalore, Karnataka: SK Pinto
Goa: Sucheta Naik
Sonari, Assam: Susanta Tanti
Nellore, Andhra Pradesh: Tejasree Beemakonda
Cochin, Kerala: Vineeth Kumar
Mumbai Central, Maharashtra: Zahra Risalawala
Anamika Nishad
Divya
Kalyani
Mamta
Sajali Dapatardar
Sakshi
Sasha Fatarpekar
Siya
Tanmay

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Yesterday CUBE Chatshaala webinar Discussed about Why Drosophila melanogaster is important studymaterial?!

6 Nobel Prizes for Drosophila melanogaster.

:pencil2:chromosomal theory of inheritance further leading to the Nobel
Prize for medicine in 1933. His work with Drosophila played
an important role in fundamental discoveries of inheritance.

:pencil2:In 1927, Muller one of the Morgans’ students studied
the hereditary characteristics of fruit flies and demonstrated
that mutations and hereditary changes can be caused by
X‑ray (Muller 1927). He also observed that higher the X‑ray
exposer higher was the frequency of mutation. This study
became the first evidence of harmful effect of X‑ray.

:pencil2:Later in
1946, Muller was awarded the Nobel Prize in physiology or
medicine for the same.
In the late 1970s and 1980s geneticist, embryologists and
molecular biologists started working together, and Drosophila
research became a great hit.

:pencil2:Edward B Lewis along with Christiane Nusslein
Volhard and Eric F Wieschaus was awarded the Nobel Prize
for physiology or medicine in 1995. The study conducted
by these three scientists was on early embryo development.
Christiane Nusslein Volhard and Eric F Wieschaus were able to identify genes that were playing an important role in the
formation of body segments and body plans in Drosophila. Edward B Lewis studied how the genes were controlling the
development of specialized organs from these body segments. This discovery has helped in understanding the congenital
malformation in human.This tiny little fly has not only revolutionized the field of
genetics but also was a star in the field of immunology. When the scientists were searching an answer to the question that
how human and other organisms protect themselves from the attack of bacteria and other organisms.

:pencil2:Bruce Beutler ,Jules Hoffmann and Ralph Steinman got an answer to it while working on Drosophila.
Jules Hoffmann found that flies with mutations in Toll gene died when infected with bacteria and fungi due to lack of innate defense system, thus throwing light on receptor proteins which can recognize microorganisms and activate innate immunity. Beutler discovered that Toll‑like receptors were also present in mice, which shows that mammals and fruit flies have similar kind of molecules to activate innate immunity. Ralph Steinman discovered dendritic cells and their ability to activate T cells. Thus the signal generated by Toll‑like receptors is sensed by dendritic cells, which further activates T cells, therefore, it
avoids the destruction of body’s own molecule. This work was then awarded the Nobel Prize in 2011 for physiology or medicine.

:pencil2:Finally, again this small little creature has played a beautiful role in receiving the 2017 Nobel Prize for Physiology or Medicine. All living organisms have an internal biological clock, which helps us to keep a day and night rhythm, but the mechanism of its work was not known till date. Jeffrey C Hall, Michael Rosbash and Michael W. Young were working on fruit fly and are able to explain how the circadian rhythm is working and synchronizing with the Earth’s revolutions.

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Please quote the reference of the above information about the Nobel Prizes gathered by Drosophila melanogaster.

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Nobel_prize_for_the_fruit_fly.pdf (798.1 KB)

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