S3E62 Cube chatShaala: Exploring new ways of Learning

Meeting URL

webinar.hbcse.tifr.res.in

HBCSE Webinar

A front-end for HBCSE web conferencing server. You can create your own rooms to host sessions, or join others using a short and convenient link.

Please click on the HBCSE Webinar above to join the CUBE ChatShaala
Timing:5.30 pm to 9.30 pm

As we do it daily, CUBE chatShaala will be starting at 5.30 pm and as a continuation of it, from 8.30 pm, there will be NAIL REGENERATION WORKSHOP today in CUBE chatShaala.

Looking forward to your participation.
Thanks

CUBE ChatShaala on 9th January 2021
34 CUBists from 26 Centres had joined the webinar
Map

ANDHRA PRADESH
Nellore: Tejasree

BIHAR
Sitamarhi: Anamika Singh
Patna: Kshipra

DELHI
AND College: Aastha Ahuja
Garima Kalakoti
Dyal Singh College: Dr P. Chitralekha

JHARKHAND
Morabadi, Ranchi: Rechel Tirkey

KARNATAKA
Bangalore: Shama Sayyed

KERALA
Kozhikode: Arunima
The Cochin College, Ernakulam: Ashikha Farzana, Bhavya, Devika Devanath, Manjula Bhat, Sumayya Parveen
Thriprayar, Thrissur: Aswathy Suresh
Kandassankadavu: Lakshmy PJ
Palakkad: Neeraja Nair, Sukanya P
Thanniam, Thrissur: Sidhy PP

MAHARASHTRA
South Bombay: Arunan MC
Thane: Anshu Kadam, Hitesh Pareek
Nerul: Drishtant M Kawale
HBCSE, Mumbai: DP
Mumbai: Kaninika Ghosh
Powai: Lydia Mathew
Mulund, Mumbai: Omkar Badnale, Priti Kanade
Mira Road, Mumbai: Sana Jalili
Panvel, Navi Mumbai: Shraddha Sonawane

UTTAR PRADESH
Kanpur: Hina Mudgal
Moradabad: Kiran Yadav

WEST BENGAL
Kolkata: Batul Pipewala, Sukriti Maity

IMG_20210109_215045
09th January 2021
Whiteboard screenshots of Cube chatShaala…

Interesting Facts related to Nail growth study and Nail Regeneration study…

What’s the difference in between Growth and Regeneration ?.. How do Nails grow?..

Planaria was taken as an example in order to define what’s the Regeneration?..

IMG_20210109_215030
INTERESTING AND AMAZING

Left side drawing shows the photo of the finger Nail with the Mark was taken on 10th December 2020 and also after 27 Days that’s on 06th Jan 2021.

It has been shown that Marked has moved and the Gap was measured 5mm

What’s does that tells us?. Does Nail have grown or have regenerated?..

What would happen when the Whole Nail get off or uprooted from the finger?..
Does that Nail Regenerate?..

Are there any stem cells/Nail stem cells?..

YES THERE ARE NAIL STEM CELLS IN THE NAIL BED.
This we could say by reffering an amazing Reference (References link will be posted) shared by Kaninika which enabled us to understand that yes Nail bed has Nails
stem cells and Stem cell has the ability to either self renew or specialized or Differentiated.

But what are the Stem cells?. Can any divided cell be called as Stem cell?..

Stem cells are the dividing cell and they are the undifferentiated cells…

Further the discussion went on what’s the difference among Wound Healing, Regeneration and Cancer

Amazing input given by Batul is that Cancer can be connected to Wound healing as if there’s wound healing then cell will stop dividing…(Reference link will be shared)…

How the Nail Growth study is connected to this Amazing Nail Regeneration study?..

References shared during the discussion
1. PNAS


A team of researchers has identified a new population of nail stem cells, which have the ability to either self-renew or undergo specialization or differentiation into multiple tissues.
Under normal circumstances, the stem cells contribute to the growth of both the nails and the adjacent skin. However, if the nail is injured or lost, a protein called “Bone Morphogenic Protein,” or BMP, signals to the stem cells to shift their function exclusively to nail repair.

Science Daily
https://www.sciencedaily.com/releases/2014/11/141121102922.htm#:~:text=A%20team%20of%20researchers%20has,or%20differentiation%20into%20multiple%20tissues.&text=Under%20normal%20circumstances%2C%20the%20stem,nails%20and%20the%20adjacent%20skin.

2. BMP signaling in skeletal system. BMPs play a crucial role in bone and cartilage formation, providing the namesake for this family of proteins, https://www.google.com/search?client=firefox-b-d&q=BMP+protein+role

3. Wnt activation in nail epithelium couples nail growth to digit regeneration
https://pubmed.ncbi.nlm.nih.gov/23760480/

4. Nail Growth Evaluation and Factors Affecting Nail Growth
https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-32383-1_121

5.https://www.livescience.com/65277-why-fingernails-keep-growing.html
As keratin cells form at the root, they’re slowly pushed forward by newly-formed cells jostling for space behind them. Edged out from beneath the skin and into the open, the older cells flatten and harden to form the tough shield of the nail plate. “Continuous division of matrix cells pushes the nail plate forward over the nail bed at a rate of about 3 millimeters [0.1 inches] per month for fingernails, and 1 millimeter [0.04 inches] per month for toenails,” said Amanda Meyer, a lecturer in human anatomy at the University of Western Australia