S3E68 Cube chatShaala: Exploring new ways of Learning

Meeting URL

webinar.hbcse.tifr.res.in

HBCSE Webinar

A front-end for HBCSE web conferencing server. You can create your own rooms to host sessions, or join others using a short and convenient link.

Please click on the HBCSE Webinar above to join the CUBE ChatShaala
Timing:5.30 pm to 9.30 pm

As we do it daily, CUBE ChatShaala will be starting at 5.30pm and as a continuation of it, from 8.30pm, there will be MangoMapping workshop

Webinar will be recorded and recording link will be post in the same thread after the webinar.

Looking forward to your participation.
Thanks

297th day of CUBE ChatShaala: 15th January 2021
47 CUBists from 41 Centres had joined the webinar
Map

ANDHRA PRADESH
Nellore: Anuhya Mucheli, Tejasri

ASSAM
Narsing High School, Silchar: Hasina Begam
Jorhat: Ishita Sonowal
Sonari: Susanta Tanti

BIHAR
Sitamarhi: Anamika Singh

DELHI
AND College: Aastha Ahuja
Dyal Singh College: Dr P. Chitralekha
DDU College: Dr Sudhir Verma
Kirori Mal College: Dr Yamal Gupta

HARYANA
Faridabad: Rahul Kushwaha

JHARKHAND
Kokar, Ranchi: Man Masih Beck
Kanke, Ranchi: Ram Deepak
Morabadi, Ranchi: Rechel Tirkey

KERALA
Kozhikode: Arunima, Theertha
Thriprayar, Thrissur: Aswathy Suresh
Kandassankadavu: Lakshmy PJ
Palakkad: Neeraja Nair, Sukanya P
Thanniam, Thrissur: Sidhy PP

MADHYA PRADESH
Gwalior: Dr Komal Singh

MAHARASHTRA
South Bombay: Arunan MC
Ghatkopar, Mumbai: Anjanikumar Kashyap
Thane: Anshu Kadam, Harsh Chindarkar, Hitesh Pareek
Nerul: Drishtant M Kawale
HBCSE, Mumbai: DP
Mumbai: Kaninika Ghosh
Powai: Lydia Mathew
Andheri, Mumbai: Mandar Chavan
Byculla, Mumbai: Nazish Kaunchale
Worli, Mumbai: Prarthana
Bandra, Mumbai: Saida Sayyed
Kalyan: Shivam Kumar Sriwas
Panvel, Navi Mumbai: Shraddha Sonavane
Chembur: Suheet Sonawane

RAJASTHAN
Jaipur: Dr Sumita Kacchwaha

TAMIL NADU
Chennai: Subhshree

UTTAR PRADESH
Kanpur: Hina Mudgal
Moradabad: Kiran Yadav

WEST BENGAL
Kolkata: Batul Pipewala, Sukriti Maity
Garden High School, Kalyani: Koulab Mukherjee

Ash
Larissa

IMG_20210115_204700
15th January 2021
WHITEBOARD SCREENSHOTS
What CUBE does?. Gives context to the Curriculum…

Zebar fish: the model can be used to study the Immune System.
Discussion got started on Do Neurons/Neuronal cells divide?.

Do Adult/Matured Neurons divide? If yes than How and if No than why?..
IMG_20210115_204650
We all have learned from our textbook is that Neurons don’t have centrioles…

There was an interesting discussion went on… Hitesh said Neurons can divide but on certain situations…

Somebody said that Neurons can’t divide…
So there were some points which we listed down addressed by Cubists during the discussion and tried to prove that why Neurons won’t divide.

Why Adult/Matured Neurons don’t divide?.
1. Neurons don’t have any centrioles as during division centrioles formation is crucial

2. Rest in G0 Phase of cell division

3. Neuronal cells are terminally differentiated
Yes these are the big terms so let’s discuss again and try to understand as we did in the Cube chatShaala

4. Neural stem cells
The conclusion is that whether Neuronal cells can divide or not.
Pre-existing Neuronal cell can’t divide above listed three points could be the reason…

But the fourth point says that the Neural stem cells has the ability to divide and this can be proved in the Model system : Earthworm
When a cut is made in between the body of Earthworm the Anterior part Which carries Clitellum would regenerate…
Let’s discuss this in details.

Another point the came out is that Neuronal cell could convert in to Pluripotent cell as per the references shared by Dr. Arunan.

YAMANAKA was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent

IMG_20210115_204628

What could be the possibility that Cells could be convert in to Pluripotent is by activating some genes related to that…

So how genes get activate so Moina model system was introduced in order to discussed that how other three genes of Haemoglobin get activating at lower oxygen level hence results in Red coloured Moina.

References shared during the Discussion
The vertebrate olfactory system has become an important model for the study of neural regeneration. The most remarkable feature of this system is its unique capacity for neurogenesis and replacement of degenerating receptor neurons. This replacement is made possible by a persistent neurogenesis among basal cells.https://pubmed.ncbi.nlm.nih.gov/1752165/

The most remarkable feature of this system is its unique capacity for neurogenesis and replacement of degenerating receptor neurons. This replacement is made possible by a persistent neurogenesis among basal cells.https://pubmed.ncbi.nlm.nih.gov/1752165/

https://www.ncbi.nlm.nih.gov/books/NBK10920/

Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development.
https://www.google.com/search?client=firefox-b-d&q=neuronal+stem+cells

In fact, this process is not a true “regeneration” like that observed in limb or heart regeneration in newts [10]. The liver does not recover the original lobular structure; rather, the remnant tissue simply increases in size (Figure 1A). Although the term, “compensatory hyperplasia” more accurately describes this phenomenon, we use “liver regeneration” in this review, as it has been used widely. https://celldiv.biomedcentral.com/articles/10.1186/1747-1028-8-8

…regeneration after surgical resection of a portion of the liver (partial hepatectomy, PHx) does not require such stem/progenitor cells; the remnant tissue undergoes hyperplasia to recover the original liver mass within about two weeks in rodents (Figure 1A and 1B) [6–9]. https://celldiv.biomedcentral.com/articles/10.1186/1747-1028-8-8

The vertebrate olfactory system has become an important model for the study of neural regeneration. The most remarkable feature of this system is its unique capacity for neurogenesis and replacement of degenerating receptor neurons. This replacement is made possible by a persistent neurogenesis among basal cells.https://pubmed.ncbi.nlm.nih.gov/1752165/

Stages of zebrafish caudal fin regeneration as longitudinal sections.
(top) The dotted line demarcates the amputation plane. The wound is closed by migrating epithelial cells to form a wound epidermis within the first 12 hours postamputation (hpa). Over the next 12 hours, the wound epidermis thickens as cells near the amputation disorganize and migrate toward the amputation plane. By 24–48 hpa, a blastema has formed https://www.ncbi.nlm.nih.gov/books/NBK27030/figure/stemcellsinanimalmodels.F2/

During terminal differentiation, a precursor cell formerly capable of cell division, permanently leaves the cell cycle, dismantles the cell cycle machinery and often expresses a range of genes characteristic of the cell’s final function (e.g. myosin and actin for a muscle cell). https://www.ncbi.nlm.nih.gov/books/NBK27030/figure/stemcellsinanimalmodels.F2/

Neurogenesis is known to occur in the adult brain, particularly in the olfactory epithelium and bulb, the dentate gyrus of the hippocampus, and the striatum. Through the process of neurogenesis, neurons in these regions of the brain can be replenished. Much has been learned about the signaling pathways and mechanisms underlying the process of neurogenesis, but many questions remain.https://www.nature.com/scitable/popular-discussion/2503/

YAMANAKA was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotenthttps://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell

Neuroblastoma is a cancer that develops from immature nerve cells found in several areas of the body.https://www.mayoclinic.org/diseases-conditions/neuroblastoma/symptoms-causes/syc-20351017

Neurogenesis is known to occur in the adult brain, particularly in the olfactory epithelium and bulb, the dentate gyrus of the hippocampus, and the striatum. Through the process of neurogenesis, neurons in these regions of the brain can be replenished.https://www.nature.com/scitable/popular-discussion/2503/

four specific genes (named Myc, Oct3/4, Sox2 and Klf4) encoding transcription factors could convert somatic cells into pluripotent stem cells.[1] https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell

most remarkable feature of this system is its unique capacity for neurogenesis and replacement of degenerating receptor neurons. This replacement is made possible by a persistent neurogenesis among basal cells. https://pubmed.ncbi.nlm.nih.gov/1752165/

Nobel prize
how cells respond to low oxygen levels have the potential to result in treatments for a variety of illnesses, today was awarded the 2019 Nobel Prize https://www.hopkinsmedicine.org/news/newsroom/news-releases/gregg-semenza-wins-2019-nobel-prize-in-physiology-or-medicine-for-hypoxia-discovery

References shared regarding the Mango-Mapping
Flowering time control in plants is essential for their reproductive success and is also an important trait in agriculture. … These signalling cues are perceived in the leaves and the shoot apical meristem (SAM) to induce flower formation.https://academic.oup.com/jxb/article/71/9/2490/5739814

Genetic and molecular basis of floral induction in Arabidopsis thaliana https://academic.oup.com/jxb/article/71/9/2490/5739814

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IMG_20210115_225900
Mango-Mapping Project Screenshot shows the data that is collected by the Cubists and registered on KoboToolBox… Total 800 Entries have been done till now. But can we make some Hypothesis by Analysing the data.
IMG_20210115_225909 Another MAP which shows the collective data(Presentable way) on Mango-Mapping study, the data shared by the Cubists from different parts of the Country.
IMG_20210115_225918

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